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Figure 2 | Frontiers in Zoology

Figure 2

From: Are ticks venomous animals?

Figure 2

Tertiary structures of tick salivary Kunitz peptides. Panel A displays tertiary structure of toxins from spider (HWTX-XI; PDB: 2JOT) and scorpion (LmKKT-1a; PDB: 2 M01), and five tick salivary Kunitz-like peptides (PDBs: TAP-1D0D; ornithodorin-1TOC; boophilin-2ODY; TdPI-2UUX; Ra-KLP-2W8X). The tertiary structures depict the conserved disulfide bridges (indicated by roman numerals), loops, β-sheets that forms the β-hairpin, and α-helices. All structures are colored from the N-terminus (blue) to the C-terminus (red). Below each tertiary structure is the respective electrostatic potential in 180° turns (blue = positive; red = negative; white = neutral). A tertiary structural alignment in Panel B depicts the Cα protein backbone (color codes for each structure is presented on the right). (Note: For Panel A we used the C-terminus domain for both ornithodorin and boophilin since these possess two Kunitz-domains).

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