Figure 6

Tertiary structures of tick salivary PLA ₂ . Panel A displays the crystal structure of the PLA₂ from bee venom of A. mellifera (PDB: 1POC) and four predicted tertiary structures, three tick PLA₂ (respective UniProt: B2D2A9, Q09JM7 and the translated sequences GenBank: EW812932) and the scorpion toxin, imperatoxin-I (UniProt: P59888). The tertiary structures depict the conserved disulfide bridges (indicated by roman numerals), loops, and the α-helix. All structures are colored from the N-terminus (blue) to the C-terminus (red). Below each tertiary structure is the respective electrostatic potential in 180° turns (blue = positive; red = negative; white = neutral). A tertiary structural alignment in Panel B depicts the Cα protein backbone (color codes for each structure is presented on the right).