Figure 4From: Comparative analysis of septic injury-inducible genes in phylogenetically distant model organisms of regeneration and stem cell research, the planarian Schmidtea mediterranea and the cnidarian Hydra vulgarisA potential perforin exist in Schmidtea that is related to other known perforins. We identified a perforin-like protein in the Schmidtea cDNA library. Using corresponding EST sequence and further EST sequences from the public database (DN313739, EG343971, DN299412, DN307006) we constructed the potential full-length protein. The alignment with perforin sequences from Haliotis corrugata (AAR82935), Homo sapiens (AAI12231), Danio rerio (XP_688214), and the sponge Suberites domuncula (CAI68018) reveal that perforins are conserved in evolution. Red color indicates 90% consensus and blue color 40% consensus.Back to article page