Fig. 7
From: MiR-34b/c play a role in early sex differentiation of Amur sturgeon, Acipenser schrenckii
Proposed model for direct targeting of the ar pathway by miR-34b/c in early sex differentiation of sturgeons. In the model, miR-34b/c interacts with female differentiation-related genes (including foxl2, cyp19a, and er) and male differentiation-related genes (dmrt1, amh, cyp11b2, and ar) via ar. Possibly, inhibition of miR-34b/c (down-regulation) and overexpression of ar (up-regulation) reduce the ovary/testis differentiation ratio, i.e., greater male-fate differentiation