Fig. 3

Most variable genes and marker genes for cell clusters in scRNAseq and snRNAseq. A UMAP of scRNAseq data. The cluster annotations are based on a combination of similar clusters to increase comparability between datasets. See Additional files 1 and 3: Fig. S4 and Table S3 for the annotation of all clusters prior to cluster merging. B Dot plot of the top four marker genes (X-axis) for each cell cluster (Y-axis) obtained after scRNAseq. The size of the dots represents the percentage of cells expressing each gene. The color intensity represents the average expression level. C UMAP of snRNAseq data. The cluster annotations are based on a combination of similar clusters to increase comparability between datasets. See Additional files 1 and 3: Fig. S7 and Table S3 for the annotation of all clusters prior to cluster merging. D Dot plot of the top four marker genes (X-axis) for each cell cluster (Y-axis) obtained after snRNAseq. The size of the dots represents the percentage of cells expressing each gene. The color intensity represents the average expression level. The gene names on the dot plots are color coded by the cluster they are enriched in, and arrows point to genes that are shared in similar clusters in scRNAseq B and snRNAseq D data. Note that the color code of the cluster identities is consistent among figures in the main text