Enteric neuroanatomy and smooth muscle activity in the western diamondback rattlesnake (Crotalus atrox)

Table 4 The effect of different drugs on the motility of the colon

Drug	N (tissue/animal)	Tone before (mN)	Tone after (mN)	p value	EFS contractile on before (mN)	EFS contractile on after (mN)	p value
Ach	12/8	8.3 [5.2/11.8]	9.2 [7.5/12.8]	0.002
Atropine	12/10	12.3 [4.6/18.6]	11.7 [4.1/19.2]	0.42	2.1 [1.0/8.8]	0.8 [0.1/2.1]	0.008
L-NAME	10/7	11.9 [9.7/22.5]	12.7 [11.0/21.9]	0.049	0.9 [0.3/2.6]	3.6 [2.4/7.3]	0.004
SNP	11/7	17.2 [5.8/19.9]	4.9 [3.7/14.3]	< 0.001
5-HT	7/4	5.9 [3.8/8.2]	4.3 [3.5/5.4]	0.109
Dopamine	7/4	11.5 [7.4/12.4]	10.8 [6.9/12.0]	0.69
Domperidone	6/3	12.1 [10.6/13.2]	12.4 [10.6/13.6]	0.438	1.5 [1.1/4.2]	2.1 [1.6/3.9]	0.438
VIP	7/4	10.3 [8.4/15.6]	8.3 [7.1/14.5]	0.036
Suramin	10/5	10.3 [5.9/13.5]	9.7 [4.8/12.6]	0.084	0.4 [0.1/1.2]	0.4 [0.1/1.7]	0.461
Propranolol	8/6	9.1 [7.4/10.3]	8.9 [7.3/10.4]	0.938	0.1 [0.0/1.2]	0.1 [0.0/1.5]	0.5
Isoproterenol	11/7	10.9 [8.8/14.3]	8.7 [6.0/10.0]	0.002	1.7 [0.9/4.4]	0.3 [0.2/2.0]	0.027
TTX	11/6	6.2 [4.0/13.1]	6.3 [4.5/12.8]	0.898	1.4 [0.4/5.0]	1.9 [0.8/3.6]	1
Lidocaine	14/7	6.5 [3.9/10.3]	17.5 [7.6/21.1]	< 0.001	2.6 [1.3/5.7]	0.0 [0.0/0.8]	0.002
Na-free Krebs sol	7/4	9.6 [6.7/10.4]	21.0 [16.8/23.0]	0.016	1.8 [0.5/3.8]	0.0 [0.0/0.3]	0.008

Changes in the muscle tone and of the response to EFS after the application of different drugs. Bold letters mean a significant effect

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